My 18 year old daughter is a long time Sims player and she has the latest version. She was showing some or the features and while there has been an attempt to make the language culture neutral, many of the other features are pretty cultural specific and reflect a consumer society.
The Sims economic system is consistent with a Western consumer labour exchange society. The avatars work in jobs, collect wages, pay bills. Their activities are largely typical consumer oriented, go to the mall, buy stuff.
Relationships are maintained in part to maintain your economic position.
I suppose that those types of consumer transactions are pretty cross-cultural.
The life style choices are broad ranging but are limited to an urban experience for the most part. No opportunity to be a pastoralist or a hunter gatherer. But I guess it is Sim City after all and it delivers as promised.